News & Stories

Researchers at The Hong Kong University of Science and Technology (HKUST) have identified for the first time the culprit behind the causing of broad-spectrum bacterial resistance to peptide antibiotics - widely perceived as the last-line of defense against antibiotic-resistant bacteria, opening a new direction to the design of new drugs in tackling superbugs. The discovery – made by Chair Professor from the Division of Life Science Prof Qian Pei-Yuan and his fellow researchers, came in the best moment as the team has also discovered that this enzyme, which they identified as the cause of broad-spectrum bacteria resistance against peptide antibiotics, was actually found in not just a few, but many different strains of bacteria, sounding an alarm against persistent improper use of antibiotics.

A research team from the Hong Kong University of Science and Technology (HKUST) has discovered a more efficient and eco-friendly way to produce a family of chiral molecules, which would potentially bring down the cost of chiral medicine and make them more accessible to all. Over half of the approved drugs now in use in the world are chiral, which treats a wide range of conditions including cardiovascular, respiratory and gastrointestinal diseases.  Many chiral drugs are top sellers including high-cholesterol medicine Lipitor, and antibiotic Amoxicillin.  But production of chiral drugs are difficult and costly, as the production process is complicated and requires rare and expensive raw materials in general.

A research team at the Hong Kong University of Science and Technology (HKUST) has demonstrated that the growth and development of two marine invertebrates – the pollution-tolerant slipper limpets and the commercially-harvested bristle worms (a common fish bait which recycles nutrients in the ecosystem) – are prone to suffer irreversible damage under exposure to high concentration of microbeads.

In our quarter century as a top academic institution, we have embarked upon an extraordinary journey in research. To this end, Research@HKUST is a must read for those seeking to learn more about the latest developments in our mission. From structural biology, to urban sustainability, humanising robots, big data, disruptive innovation, and demystifying China’s finance, HKUST has demonstrated its research breadth in addressing global and societal challenges. Indeed, HKUST topped the most recent Research Assessment Exercise by the University Grants Committee (UGC) in Hong Kong, with 70 percent of HKUST’s submissions rated either “world leading” (four star) or “internationally excellent” (three star).

An international multi-disciplinary research team led by scientists at the Hong Kong University of Science and Technology (HKUST) has discovered for the first time a computational framework that could map out the fitness landscape of a crucial protein in the human immunodeficiency virus (HIV), potentially paving the way for rational design of a vaccine that may force the deadly virus to mutate into forms that lead to its demise. Despite significant advances in medicine, an effective vaccine for HIV is still not available, although recent hope has emerged through the discovery of antibodies capable of neutralizing diverse HIV. The virus, however, can still evade known broadly neutralizing antibody responses via mutational pathways, which makes it all the more difficult to design an effective solution.

An interdisciplinary team of scientists from The Hong Kong University of Science and Technology (HKUST) has discovered the mechanism of how human brains turn on and off neuronal activities, providing an important foundation to understand a wide range of neurologic conditions such as epilepsy, Parkinson's disease and ataxia-telangiectasia diseases. “As with all things in life, healthy brain function depends on a balance of neuronal activities. We think of our brains as active - moving a leg and saying a word are all "active" events, but it is just as important that our brains be able to stop these actions,” said Cheng Aifang, a postgraduate student from the Division of Life Science who made the discovery under the guidance of the division’s head and Chair Professor Karl Herrup. “Yet it was not clear how our brains actually perform this go/stop function until now.”

A research team led by awards-winning neuroscientist and structural biologist Prof Zhang Mingjie of the Hong Kong University of Science and Technology (HKUST) has recently reached a breakthrough unveiling the fundamental mechanism that causes schizophrenia and other serious psychiatric conditions.  Such discovery may potentially lead to the development of new treatments and drugs for the mental disorders. At present, there are about 40,000 diagnosed schizophrenic patients in Hong Kong [1].

PowerSearch got a new look and new functions this summer. Not only at HKUST, but at all 8 UGC-funded university libraries (known as JULAC) as well. We have all moved onto one single online platform for you to find, access, retrieve, and request resources from the 8 UGC libraries. The aggregate collection of materials from all JULAC Libraries is known as HKALL.